Dietary restriction and lifespan: Lessons from invertebrate models.
Identifieur interne : 000875 ( Main/Exploration ); précédent : 000874; suivant : 000876Dietary restriction and lifespan: Lessons from invertebrate models.
Auteurs : Pankaj Kapahi [États-Unis] ; Matt Kaeberlein [États-Unis] ; Malene Hansen [États-Unis]Source :
- Ageing research reviews [ 1872-9649 ] ; 2017.
Descripteurs français
- KwdFr :
- Animaux (MeSH), Caenorhabditis elegans (MeSH), Drosophila (métabolisme), Drosophila melanogaster (MeSH), Facteur de croissance IGF-I (MeSH), Insuline (MeSH), Longévité (MeSH), Modèles animaux (MeSH), Protéines recombinantes (MeSH), Restriction calorique (MeSH), Saccharomyces cerevisiae (MeSH), Sirtuines (métabolisme), Sérine-thréonine kinases TOR (MeSH), Transduction du signal (MeSH).
- MESH :
English descriptors
- KwdEn :
- Animals (MeSH), Caenorhabditis elegans (MeSH), Caloric Restriction (MeSH), Drosophila (metabolism), Drosophila melanogaster (MeSH), Insulin (MeSH), Insulin-Like Growth Factor I (MeSH), Longevity (MeSH), Models, Animal (MeSH), Recombinant Proteins (MeSH), Saccharomyces cerevisiae (MeSH), Signal Transduction (MeSH), Sirtuins (metabolism), TOR Serine-Threonine Kinases (MeSH).
- MESH :
- chemical , metabolism : Sirtuins.
- chemical : Insulin, Insulin-Like Growth Factor I, Recombinant Proteins, TOR Serine-Threonine Kinases.
- metabolism : Drosophila.
- Animals, Caenorhabditis elegans, Caloric Restriction, Drosophila melanogaster, Longevity, Models, Animal, Saccharomyces cerevisiae, Signal Transduction.
Abstract
Dietary restriction (DR) is the most robust environmental manipulation known to increase active and healthy lifespan in many species. Despite differences in the protocols and the way DR is carried out in different organisms, conserved relationships are emerging among multiple species. Elegant studies from numerous model organisms are further defining the importance of various nutrient-signaling pathways including mTOR (mechanistic target of rapamycin), insulin/IGF-1-like signaling and sirtuins in mediating the effects of DR. We here review current advances in our understanding of the molecular mechanisms altered by DR to promote lifespan in three major invertebrate models, the budding yeast Saccharomyces cerevisiae, the nematode Caenorhabditis elegans, and the fruit fly Drosophila melanogaster.
DOI: 10.1016/j.arr.2016.12.005
PubMed: 28007498
PubMed Central: PMC5476520
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Despite differences in the protocols and the way DR is carried out in different organisms, conserved relationships are emerging among multiple species. Elegant studies from numerous model organisms are further defining the importance of various nutrient-signaling pathways including mTOR (mechanistic target of rapamycin), insulin/IGF-1-like signaling and sirtuins in mediating the effects of DR. We here review current advances in our understanding of the molecular mechanisms altered by DR to promote lifespan in three major invertebrate models, the budding yeast Saccharomyces cerevisiae, the nematode Caenorhabditis elegans, and the fruit fly Drosophila melanogaster.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM"><PMID Version="1">28007498</PMID><DateCompleted><Year>2018</Year><Month>03</Month><Day>22</Day></DateCompleted><DateRevised><Year>2018</Year><Month>12</Month><Day>02</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1872-9649</ISSN><JournalIssue CitedMedium="Internet"><Volume>39</Volume><PubDate><Year>2017</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Ageing research reviews</Title><ISOAbbreviation>Ageing Res Rev</ISOAbbreviation></Journal><ArticleTitle>Dietary restriction and lifespan: Lessons from invertebrate models.</ArticleTitle><Pagination><MedlinePgn>3-14</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S1568-1637(16)30288-4</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.arr.2016.12.005</ELocationID><Abstract><AbstractText>Dietary restriction (DR) is the most robust environmental manipulation known to increase active and healthy lifespan in many species. Despite differences in the protocols and the way DR is carried out in different organisms, conserved relationships are emerging among multiple species. Elegant studies from numerous model organisms are further defining the importance of various nutrient-signaling pathways including mTOR (mechanistic target of rapamycin), insulin/IGF-1-like signaling and sirtuins in mediating the effects of DR. We here review current advances in our understanding of the molecular mechanisms altered by DR to promote lifespan in three major invertebrate models, the budding yeast Saccharomyces cerevisiae, the nematode Caenorhabditis elegans, and the fruit fly Drosophila melanogaster.</AbstractText><CopyrightInformation>Copyright © 2016 Elsevier B.V. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kapahi</LastName><ForeName>Pankaj</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Buck Institute for Research on Aging, Novato, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kaeberlein</LastName><ForeName>Matt</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Pathology, University of Washington, Seattle, WA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hansen</LastName><ForeName>Malene</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA. 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